In aesthetic medicine, precision, predictability, and patient-centered outcomes are everything. So, when a new dermal filler platform is introduced—especially one with clinical backing and a heritage rooted in tissue science—it deserves careful attention. That’s exactly where we find ourselves with Evolysse Smooth and Evolysse Form, two new hyaluronic acid (HA) fillers recently approved by the FDA for the treatment of moderate to severe facial wrinkles and folds.
These products are developed by Symatese, a French medical device company with three decades of experience in tissue restoration and biomaterials, and brought to the U.S. by Evolus, known for Jeuveau®. As always, our responsibility as injectors is to look beyond marketing and understand what makes these products clinically relevant.
Understanding the Evolysse Technology
The Evolysse range is built using a proprietary Cold-X™ crosslinking process, which maintains the native HA’s integrity during formulation. The claim is that this creates a filler with enhanced rheological stability, improved tissue integration, and minimal initial swelling.
From a practical standpoint, this means:
- Less post-treatment edema
- Greater control during injection
- Smoother integration into the dermis and subdermis
Both Smooth and Form are pre-mixed with lidocaine, a standard in modern filler design, ensuring patient comfort.
Let’s explore the two products individually and examine their applications in clinic.
Evolysse Smooth: Precision for Dynamic and Superficial Correction
Indications: Moderate nasolabial folds, marionette lines, superficial rhytids, and fine contouring.
Technical Notes:
- Designed for mid-to-superficial dermis placement
- Exhibits low extrusion force, facilitating fine control
- Balanced cohesivity and moldability, allowing gentle adaptation to dynamic areas
Clinical Considerations:
Evolysse Smooth is best compared with products like Juvederm Vollure or Restylane Refyne, where softness, spreadability, and superficial placement are required. Ideal for patients who want to retain expressiveness with minimal palpability or projection.
In a multicenter FDA trial, results showed sustained correction up to 12 months with high patient satisfaction. This is encouraging, particularly for patients reluctant to undergo frequent retreatment.
Evolysse Form: Structure Meets Subtlety
Indications: Midface volume loss, jawline contouring, chin projection, and deep nasolabial folds.
Technical Notes:
- Placed in the deep dermis or subcutaneous layer
- High G’ (elastic modulus) provides support and lift
- Maintains a smooth extrusion profile despite its density
Clinical Considerations:
In terms of performance, this filler aligns with Juvederm Voluma, Restylane Lyft, or Teosyal RHA 4—but its cohesivity feels slightly more refined. The Cold-X™ process appears to reduce the hydrophilic response, which may translate to less swelling, especially in deeper planes.
This makes Evolysse Form particularly useful for structural work in the midface, jawline, and chin, where accuracy and post-treatment appearance are crucial.
Integrating Evolysse Into Your Aesthetic Practice
As injectors, one of our challenges is product selection—understanding how a filler behaves in tissue, how it feels under the cannula or needle, and how the patient experiences the result.
What stands out with Evolysse is its thoughtful engineering. Both fillers offer:
- Low swelling and downtime
- Predictable tissue behavior
- Tactile control, especially for advanced injectors
Importantly, Evolysse offers a streamlined portfolio—Smooth for finer, superficial work; Form for deeper structure—without the confusion of multiple overlapping SKUs.
Safety and Dosing Considerations
Both Smooth and Form come in 1.0 mL syringes, pre-mixed with 0.3% lidocaine, and are non-animal stabilized HA. The safety profile in the FDA studies showed minimal adverse events, with the most common being injection site swelling, tenderness, and bruising—similar to other HA fillers.
It’s always essential to remind patients about aftercare and expected outcomes and to use anatomical guidance and aspiration techniques when appropriate to minimize vascular risk.
Final Thoughts: Clinical Promise with Cautious Optimism
What is Evolysse(Evolysse) is not a reinvention of the wheel—but it is a refinement. For clinicians who are focused on outcomes, tissue behavior, and minimizing adverse effects, the Evolysse platform may offer meaningful advantages. Like all new products, clinical experience over time will validate whether these theoretical advantages play out consistently across patient demographics and facial regions.
That said, Evolysse Smooth and Form are welcome additions to the toolkit of medical aesthetic practitioners who value subtlety, precision, and patient comfort.
Ready to introduce Evolysse into your clinical practice?
Make sure your foundation is strong—understand rheology, facial anatomy, and patient selection. As always, it’s not just the product, it’s the technique and intent behind the injection that makes all the difference. Are you ready to expand your aesthetic practice and offer your patients the latest neuromodulator options? Join Cosmetic Medical Training and take your Botox training certification and Evolysse Training today!
