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Complication Management of Restylane® / Perlane®

HA fillers have an impressive safety record.  Despite this impressive safety record, adverse events occur when injecting HA fillers.  It is important to be familiar with potential complications and management. Complication can be divided into early and delayed in time of occurrence, and minor and major in severity. Early minor complications include bruising, pain, edema . . .

Restylane® / Perlane®

In 1893, the first fat auto-grafting was performed by Dr. Neuber, who successfully auto-grafted fat into the infraorbital margin in a man with tuberculous ostitis. In 1980’s Dr. Fournier injected fat from liposuction surgery. Average fat survival rate was around 25%. Bovine collagen was developed in the 1970’s and Zyderm implant was FDA approved in 1983.

Clinical Study of Dysport/Restylane/Perlane Injection Technique

Three double-blind, randomized, placebo-controlled, clinical studies evaluated the efficacy of Dysport® for use in the temporary improvement of the appearance of moderate to severe glabellar lines. These 3 studies enrolled healthy adults (ages 19—75) with glabellar lines of at least moderate severity at maximum frown.